Pharmaceutical API

Pharmaceutical API Micronization

For API trials, formulation development, and particle size control verification, focus on low-temperature grinding, particle size consistency, clean contact materials, and scale-up testing.

API grinding should be verified by testing

APIs differ in hardness, heat sensitivity, static behavior, moisture absorption, and agglomeration. Lab jet milling helps evaluate target particle size, temperature rise, yield, and batch consistency before scale-up.

Key Focus

Target particle size, temperature rise, recovery rate, batch consistency, contact material, cleaning, and inert gas requirement.

Recommended Configuration

Fluidized Bed Jet Mill

For pilot or production scale with classifier-based particle size control.

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Clean Contact Parts

Contact materials and cleanable structures selected according to process requirements.

Particle Size Testing

D50, D90, and D97 can be confirmed through test reports.

Low Temperature Grinding

Jet milling can help reduce temperature rise for selected heat-sensitive powders.

Scale-Up Advice

Testing results support pilot and production model selection.